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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.9 or 1.0 mg/h. In addition, there were no significant differences in serum cortisol levels among the three classes of steroid. A significant increase in both cortisol levels and the incidence of hypofusions was observed with increasing dose values in patients treated with prednisolone. The authors of this study caution that their study has important limitations. One limitation is the inclusion of patients who are treated with prednisolone despite their desire to discontinue that therapy. Moreover, there were no data on the frequency of the adverse event that is the most commonly reported adverse event in pediatric patients receiving corticosteroids for the treatment of asthma. Another limitation is the non-randomized assignment and the lack of information regarding the timing of the study in order to prevent confounding by other medications used. Although the study did not consider the use of corticosteroids in asthma as a potential confounder, there were no statistically significant differences in risk of adverse events within the three classes of steroid when corticosteroids were compared to a "reference" group that did not receive inhalational corticosteroids. The authors of this study concluded that a single dose of prednisolone is adequate for the management of pediatric asthma. References: 1. Pediatric Asthma. 2008 November. 15(11):1737-1742. http://www.pediatrics.org/cgi/reprint/15/11/1737.full.html [accessed October 11, 2016]. 2. Eysenck M, Beekman K, Tjรธnneland A. Effects of corticosteroids on cardiovascular risk factors and systemic inflammation in children. Anal Chim Acta 2013; 1466:845-852. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207766/?tool=pubmed [accessed October 11, 2016]. 3. Anderson RC, Anderson JA, Stuckler JG. Effects of corticosteroids on the pulmonary function in children with asthma. Arch Pediatr Adolesc Med 1996;141:1033-1042. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1213110/?tool=pubmed [accessed October 11, 2016]. 4. Hwang J, Lee SH, Lee YS. Effect of the steroids Similar articles:
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